کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1384347 | 982401 | 2013 | 4 صفحه PDF | دانلود رایگان |
Glycosaminoglycans and its derivatives have gained increasing attention for the fabrication of hydrogels usable in biomedicine. Starting from high molecular weight hyaluronan, a natural glycosaminoglycan that forms a mayor component of the native extracellular matrix, we present an efficient phase-transfer-based synthesis for low molecular weight hyaluronan acrylates with a tailored degree of substitution (DS) ranging up to DS values of 1.7. The ability of these compounds to form dimensionally stable hydrogels was proven using different photo-initiator systems.
► Hyaluronan acrylates were prepared using phase-transfer conditions.
► High degrees of acrylation ranging up to 1.7 per disaccharide repeating unit are accessible.
► Synthesized hyaluronan acrylates form dimensionally stable hydrogels by UV or visible light initiated photo-crosslinking.
Journal: Carbohydrate Polymers - Volume 93, Issue 2, 2 April 2013, Pages 438–441