Synthetic analogues of mycobacterial arabinogalactan linkage-disaccharide part II: synthesis and preliminary screening of lipophilic O-alkyl glycosides

Lipophilic analogues of the linkage-disaccharide found in the mycobacterial cell wall were synthesized and the synthetic analogues when biologically evaluated showed promising antimycobacterial property with MIC value in the range 3.13–12.50 μg/mL against Mycobacterium tuberculosis H37Rv.

A set of mycobacterial arabinogalactan linkage-disaccharide analogues with lipophilic character were synthesized and screened against Mycobacterium tuberculosis H37Rv. Results were promising with MIC values in the range 3.13–12.50 μg/mL.Figure optionsDownload as PowerPoint slide