کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1384635 | 982412 | 2010 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
An efficient conversion of N-acetyl-d-glucosamine to N-acetyl-d-galactosamine and derivatives
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: An efficient conversion of N-acetyl-d-glucosamine to N-acetyl-d-galactosamine and derivatives An efficient conversion of N-acetyl-d-glucosamine to N-acetyl-d-galactosamine and derivatives](/preview/png/1384635.png)
چکیده انگلیسی
2-Acetamido-2-deoxy-d-galactose (d-GalNAc) is an important monosaccharide widely distributed in nature. However, unlike its 4-epimer, the 2-acetamido-2-deoxy-d-glucose (d-GlcNAc), d-GalNAc is very expensive to obtain from commercial sources. Herein we report an efficient transformation that allows for the conversion of d-GlcNAc to a d-GalNAc derivative 7 in three steps and in 58.4–75% overall yields. The process was carried out on a greater than 20-g scale without the need of chromatography. The versatility of compound 7 was demonstrated by the synthesis of several useful monosaccharides and thiodisaccharides containing a d-GalNAc residue.
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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Carbohydrate Research - Volume 345, Issue 17, 22 November 2010, Pages 2450–2457
Journal: Carbohydrate Research - Volume 345, Issue 17, 22 November 2010, Pages 2450–2457
نویسندگان
Jianhao Feng, Chang-Chun Ling,