کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1384646 | 982412 | 2010 | 5 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Phenolic Glycosides with antiproteasomal activity from Centaurea urvillei DC. subsp. urvillei Phenolic Glycosides with antiproteasomal activity from Centaurea urvillei DC. subsp. urvillei](/preview/png/1384646.png)
A new flavanone glycoside, naringenin-7-O-β-d-glucuronopyranoside, and a new flavonol glycoside, 6-hydroxykaempferol-7-O-β-d-glucuronopyranoside were isolated together with 12 known compounds, 5 flavone glycoside; hispidulin-7-O-β-d-glucuronopyranoside, apigenin-7-O-β-d-methylglucuronopyranoside, hispidulin-7-O-β-d-methylglucuronopyranoside, hispidulin-7-O-β-d-glucopyranoside, apigenin-7-O-β-d-glucopyranoside, a flavonol; kaempferol, two flavone; apigenin, and luteolin, a flavanone glycoside; eriodictyol-7-O-β-d-glucuronopyranoside, and three phenol glycoside; arbutin, salidroside, and 3,5-dihydroxyphenethyl alcohol-3-O-β-d-glucopyranoside from Centaurea urvillei subsp. urvillei. The structure elucidation of the new compounds was achieved by a combination of one- (1H and 13C) and two-dimensional NMR techniques (G-COSY, G-HMQC, and G-HMBC) and LC–ESI-MS. The isolated compounds were tested for their antiproteasomal activity. The results indicated that kaempferol, a well known and widely distributed flavonoid in the plant kingdom, was the most active antiproteasomal agent, followed by apigenin, eriodictyol-7-O-β-d-glucuronopyranoside, 3,5-dihydroxyphenethyl alcohol-3-O-β-d-glucopyranoside, and salidroside, respectively.
Two new compounds, naringenin-7-O-β-d-glucuronopyranoside and 6-hydroxykaempferol-7-O-β-d-glucuronopyranoside were isolated from Centaurea urvillei DC. subsp. urvillei. The isolated compounds were tested for their antiproteasomal activity. The results indicated that kaempferol, a widely distributed flavonoid in the plant kingdom, was the most active antiproteasomal agent.Figure optionsDownload as PowerPoint slide
Journal: Carbohydrate Research - Volume 345, Issue 17, 22 November 2010, Pages 2529–2533