کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1384756 | 982417 | 2010 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Synthesis of γ-aminobutyric acid analogs based on carbohydrate scaffolds
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Synthesis of γ-aminobutyric acid analogs based on carbohydrate scaffolds Synthesis of γ-aminobutyric acid analogs based on carbohydrate scaffolds](/preview/png/1384756.png)
چکیده انگلیسی
γ-Aminobutyric acid analogs based on sugar scaffolds were prepared in six to nine steps starting from d-glucal and d-galactal. The key step in the synthesis is the Vilsmeier–Haack reaction that affords the corresponding 2-C-formyl glycal on treatment with DMF and POCl3. Oxidation of the aldehyde and reduction of the 4-azido group provided the corresponding GABA analog. Acylamide and tetrazole analogs were also prepared as the bioisosteres of the carboxylic acid.
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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Carbohydrate Research - Volume 345, Issue 9, 16 June 2010, Pages 1099–1106
Journal: Carbohydrate Research - Volume 345, Issue 9, 16 June 2010, Pages 1099–1106
نویسندگان
Ming Zhong, Xiang-Bao Meng, Zhong-Jun Li,