کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1384942 982425 2012 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Core cross-linked hyaluronan-styrylpyridinium micelles as a novel carrier for paclitaxel
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Core cross-linked hyaluronan-styrylpyridinium micelles as a novel carrier for paclitaxel
چکیده انگلیسی

In this study, cross-linked hyaluronan-styrylpyridinium (HA-SbQ) micelles were prepared to be used as a novel carrier for paclitaxel (PTX). PTX was successfully encapsulated into the hydrophobic cores of the cross-linked micelles using the dialysis method. The resultant PTX-loaded cross-linked HA-SbQ micelles were about 113 nm in diameter with spherical shape and high encapsulation efficiency. Fluorescence microscopy and high-performance liquid chromatography studies showed that PTX-loaded cross-linked HA-SbQ micelles had excellent cellular uptake ability by bone marrow derived macrophages (BMM) and human glioma U87 cells. Cellular uptake of cross-linked HA-SbQ micelles was found to be higher than that of un-cross-linked ones due to smaller size and more stable structure. In vitro cytotoxicity studies also revealed that the PTX-loaded cross-linked micelles were more potent than those of PTX-loaded un-cross-linked micelles and free PTX. These results suggested that cross-linked HA-SbQ micelles could be a potential vehicle for delivering hydrophobic chemotherapeutic drugs to tumors.


► Cross-linked hyaluronan-styrylpyridinium micelles were prepared.
► Paclitaxel was successfully encapsulated into the cross-linked micelles.
► Paclitaxel-loaded cross-linked micelles had excellent cellular uptake ability.
► Paclitaxel-loaded cross-linked micelles significantly reduced tumor cell viability.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Carbohydrate Polymers - Volume 88, Issue 1, 17 March 2012, Pages 118–124
نویسندگان
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