کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1385380 | 982443 | 2007 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Preparation and characterization of biodegradable alkylether derivatives of hyaluronan
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Series of partially hydrophobic and water soluble alkyl ether hyaluronans were prepared. The conditions of chemical reaction of alkyloxymethyloxiranes with hydroxyl groups of hyaluronan (HA) were examined. Varying reagent ratio, amount of DMSO, pH, original molecular weight (Mw) and reaction time affected the formation of the products and derivatives with various degree of substitution (DS) and Mw can be obtained. All novel HA derivatives were fully biodegradable with testicular hyaluronidase. Tests for chondrocyte adhesion, proliferation, as well as their differentiation marker production on the surfaces containing HA derivatives showed better or equal quality as original HA.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Carbohydrate Polymers - Volume 69, Issue 2, 1 June 2007, Pages 344-352
Journal: Carbohydrate Polymers - Volume 69, Issue 2, 1 June 2007, Pages 344-352
نویسندگان
Petra MlÄochová, Veronika Hájková, Bohumil Steiner, SlavomÃr Bystrický, Miroslav KoóÅ¡, Martina Medová, VladimÃr Velebný,