کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1385603 | 982452 | 2006 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Synthesis of new analogues of salacinol containing a pendant hydroxymethyl group as potential glycosidase inhibitors
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Synthesis of new analogues of salacinol containing a pendant hydroxymethyl group as potential glycosidase inhibitors Synthesis of new analogues of salacinol containing a pendant hydroxymethyl group as potential glycosidase inhibitors](/preview/png/1385603.png)
چکیده انگلیسی
The synthesis of new analogues of the naturally occurring glycosidase inhibitor, salacinol, and its ammonium analogue, ghavamiol is described. These analogues contain an additional hydroxymethyl group at C-1, which was intended to form additional polar contacts within the active site of glycosidase enzymes. The target zwitterionic compounds were synthesized by means of nucleophilic attack at the least hindered carbon atom of 2,4-O-benzylidene-l (or d)-erythritol 1,3-cyclic sulfate by 2,5-anhydro-1,3:4,6-di-O-benzylidene-2,5-dideoxy-5-thio (or 1,5-imino)-l-iditol.
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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Carbohydrate Research - Volume 341, Issue 14, 16 October 2006, Pages 2305–2311
Journal: Carbohydrate Research - Volume 341, Issue 14, 16 October 2006, Pages 2305–2311
نویسندگان
Ravindranath Nasi, B. Mario Pinto,