کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1385941 | 982463 | 2006 | 10 صفحه PDF | دانلود رایگان |

Ganoderma lucidum polysaccharides (Gl-PS) have shown a variety of immune modulating effects. Culture of immunologic effector cells termed cytokine induced killer (CIK) cells is dependent on exogenous cytokines. It is not known about effects of Gl-PS on cytokine production, perforin and granzyme B expression in CIK cells. We made use of CIK cells as a means to investigate interaction between Gl-PS and cytokines, and explore mechanism of Gl-PS acting on proliferation and anti-tumor activity of CIK cells. The results suggested that Gl-PS (400 or 100 μg/ml) promoting CIK cells proliferation and cytotoxicity were relevant to enhancing IL-2, TNF production, protein and mRNA expression of granzyme B and perforin in CIK cells through synergizing cytokines in decreasing doses of IL-2 and anti-CD3 by 75 and 50%, and maybe were irrelevant to nitric oxide (NO). These results confirmed that Gl-PS was a promising biological response modifier (BRM) and immune potentiator.
Journal: Carbohydrate Polymers - Volume 63, Issue 2, 3 February 2006, Pages 188–197