کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1386006 982467 2009 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synthesis and characterization of superparamagnetic nanoparticles coated with carboxymethyl starch (CMS) for magnetic resonance imaging technique
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Synthesis and characterization of superparamagnetic nanoparticles coated with carboxymethyl starch (CMS) for magnetic resonance imaging technique
چکیده انگلیسی

Magnetic nanoparticles have been proposed for use as biomedical purposes to a large extent for several years. The development of techniques that could selectively deliver drug molecules to the diseased site, without a concurrent increase in its level in healthy tissues, is currently one of the most active areas of cancer research. The conjugate carboxymethyl starch (CMS)/SPIO nanoparticles were prepared by chemical reaction. Several parameters including the drug/polymer ratios in range of 1:14 were examined to optimize formulation. The size distribution and morphology of nanoparticles and in vitro release profile in phosphate buffer medium (pH 7.4) during 12 h were then investigated. The magnetic NPs prepared in this study were spherical with a relatively mono-dispersed size distribution. The conjugate carboxymethyl starch (CMS)/SPIO nanoparticles were exhaustively studied as controlled-release systems for parenteral administration of a model drug 5-aminosalicyclic acid (mesalamine) and analyzed using various release kinetic studies.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Carbohydrate Polymers - Volume 78, Issue 2, 5 September 2009, Pages 292–295
نویسندگان
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