کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1386307 | 982491 | 2009 | 5 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Investigation diffusion mechanism of β-lactam conjugated telechelic polymers of PEG and β-cyclodextrin as the new nanosized drug carrier devices Investigation diffusion mechanism of β-lactam conjugated telechelic polymers of PEG and β-cyclodextrin as the new nanosized drug carrier devices](/preview/png/1386307.png)
Six new prodrugs including conjugated telechelic polymer of β-cyclodextrin-poly (ethylene glycol)-β-cyclodextrin (β-CD-PEG- β-CD) and or parent β-cyclodextrin (β-CD) were designated as the new drug carrier agents containing β-lactam antibiotics such as ampicillin (AMP), amoxicillin (AMO) and cephalexin (CEP) prodrugs for potentially local administration pharmaceutical applications. Investigation of the drug release dynamics in buffered media with pH 7.4 showed that the drug released through the prodrug matrix with slightly deviation, follows Fickian diffusion mechanism. Using equation “log (Mt/M∞) = log k + n log t” it has revealed that the synthesized prodrugs 5a–c, 6a–c have the “n” values 0.333, 0.334, 0.390, 0.540, 0.514 and 0.473, respectively. In fact, the prodrug 6c showed the least deviation from Fickian diffusion mechanism.
Journal: Carbohydrate Polymers - Volume 76, Issue 1, 2 March 2009, Pages 46–50