کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1386905 | 982540 | 2011 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Evaluation of hot-water extracted arabinoxylans from ispaghula seeds as drug carriers
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Evaluation of hot-water extracted arabinoxylans from ispaghula seeds as drug carriers Evaluation of hot-water extracted arabinoxylans from ispaghula seeds as drug carriers](/preview/png/1386905.png)
چکیده انگلیسی
This work evaluates the potential of a hot water extracted arabinoxylan from ispaghula (Plantago ovata) seeds as a safe, effective and economical drug carrier. In thermal analysis integral procedural decomposition temperature and comprehensive index of thermal stability were found to be 308 °C and 0.47 respectively. Gel permeation chromatography showed the existence of two components in the fraction. Atomic force microscopy indicated a surface having nanostructure. The tablets incorporating caffeine and diclofenac sodium formulated by the use of arabinoxylan exhibited sustained release profiles in various media. A pH-independent release pattern was observed for caffeine, while for diclofenac sodium the profile was found to be pH-dependent. The arabinoxylan provided a better sustained release as compared with that of Voltral®, a standard diclofenac sodium preparation. The release data suggest Power Law an appropriate model for this system.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Carbohydrate Polymers - Volume 83, Issue 3, 30 January 2011, Pages 1218-1225
Journal: Carbohydrate Polymers - Volume 83, Issue 3, 30 January 2011, Pages 1218-1225
نویسندگان
Mohammad S. Iqbal, Jamshed Akbar, Muhammad A. Hussain, Shazia Saghir, Muhammad Sher,