کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1386920 982540 2011 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Preparation and investigation of a cross-linked hyaluronan nanoparticles system
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Preparation and investigation of a cross-linked hyaluronan nanoparticles system
چکیده انگلیسی

The present paper describes the preparation and characterization of hydrophilic hyaluronan nanoparticles formed by cross-linking of hyaluronic acid (HA) with 2,2′(ethylenedioxy)bis(ethylamine) in the presence of water-soluble carbodiimide (CDI) in aqueous media. The particle size of cross-linked nanosystems was measured by dynamic light scattering (DLS) and transmission electron microscopy (TEM), transmittance by UV–VIS spectrophotometry, gel permeation chromatography (GPC) and rheology to characterize the physico-chemical properties.The aqueous nanosystems prepared were stable, transparent or mildly opalescent with values of transmittance above 91%. It was observed, that a fraction of particles with size less than 20 nm, has been released during the purification by diafiltration. It was established that the hydrodynamic size of cross-linked HA nanoparticles can be controlled by variation of the reaction conditions such as concentration of HA, salt concentration of media, ratio of cross-linker and the final pH of the reaction mixture.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Carbohydrate Polymers - Volume 83, Issue 3, 30 January 2011, Pages 1322–1329
نویسندگان
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