کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1387076 | 982545 | 2011 | 9 صفحه PDF | دانلود رایگان |
There is a demand for a wound dressing which can be removed from the application site easily without causing any pain or discomfort. A material removable by manipulating the temperature (e.g. moisten with ice cold water), from that point of view, seems to have considerable potential. Here we report a new formulation consisting of thiolated chitosan with poly(N-isopropyl acrylamide) loaded with ciprofloxacin. The thermoresponsive material was cytocompatible and was found to modulate the release of the incorporated ciprofloxacin in a sustained fashion reflecting its suitability to protect a wound for a prolonged period. The film exhibited adequate mechanical strength and was removable from a substrate (e.g. tissue culture plate) by lowering the temperature. The combination of thiolated chitosan with poly(N-isopropyl acrylamide) and ciprofloxacin showed antibacterial properties to the virulent bacteria E coli supporting its potential as a wound dressing.
Journal: Carbohydrate Polymers - Volume 83, Issue 2, 10 January 2011, Pages 705–713