کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1387080 | 982545 | 2011 | 6 صفحه PDF | دانلود رایگان |
The chemically modified polysaccharides, including sulfated, phosphorylated, carboxymethylated, acetylated and sulfonylated derivatives, were prepared from a neutral polysaccharide (PD) extracted from Polygonatum cyrtonema Hua. These compounds were characterized by FT-IR, 1H NMR and 13C NMR spectroscopy. Antiherpetic activities of natural and modified P. cyrtonema polysaccharide against herpes simplex virus (HSV) induced by cyclophosphamide (CP) were then evaluated on vero cells using cytopathic effect (CPE) inhibition assay. The phorphorylated derivative (P-PD) and sulfated derivative (S-PD), exhibited significant inhibitory activity against HSV in comparison with the native ones, especially, P-PD presented better antiviral potency. In addition, the sulfonylated derivative (Ts-PD) was found to be as effective as PD, and the acetylated derivative (Ac-PD) to be slightly less antiviral effective, whereas carboxymethylated derivative (C-PD) was shown to be almost inactive. The results indicated that the types of function groups appeared to be very important for the antiherpetic activity of polysaccharides.
Journal: Carbohydrate Polymers - Volume 83, Issue 2, 10 January 2011, Pages 737–742