Synthesis of glycotriazololipids and observations on their self-assembly properties

• Various glycotriazololipids were prepared by dry grinding.
• The glycotriazololipids formed supramolecular structures through self-assembly.
• The self-assembly was proved temperature and solvent-dependent.
• The sugar & the lipid structures influenced the structure of the assemblages formed.

Various carbohydrate-anchored triazole-linked lipids prepared by solvent-free mechanochemical azide-alkyne click reaction, on analysis by TEM, have been found to spontaneously self-assemble in solvents leading to structures of interesting physicochemical attributes. Interestingly, analogous compounds based on different sugars (e.g., d-glucose, and d-galactose, as also d-lactose) assemble in patterns distinctly different from each other thus reiterating the fact that the structure of the sugar as well as that of the lipid are important factors that determine the size and shape of the supramolecular assembly formed. Besides, the molecular self-assembly was also found to be solvent-as well as temperature-dependent.

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