کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1387687 1500819 2016 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Functional analysis of anomeric sugar kinases
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Functional analysis of anomeric sugar kinases
چکیده انگلیسی

Anomeric sugar kinases perform fundamental roles in the metabolism of carbohydrates. Under- or overexpression of these enzymes, or mutations causing functional impairments can give rise to diseases such as galactosaemia and so the study of this class of kinase is of critical importance. In addition, anomeric sugar kinases which are naturally promiscuous, or have been artificially made so, may find application in the synthesis of libraries of drug candidates (for example, antibiotics), and natural or unnatural oligosaccharides and glycoconjugates. In this review, we provide an overview of the biological functions of these enzymes, the tools which have been developed to investigate them, and the current frontiers in their study.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Carbohydrate Research - Volume 432, 2 September 2016, Pages 23–30
نویسندگان
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