The structure of the Morganella morganii lipopolysaccharide core region and identification of its genomic loci

• Morganella morganii LPS core part structure is reported for the first time.
• The structure resembles the structures of LPS cores from related bacteria-Proteus and Providencia.
• Genes required for the core biosynthesis were identified by homology with related organisms.

The core region of the lipopolysaccharide of Morganella morganii serotype O:1ab was obtained by hydrolysis of the LPS and studied by 2D NMR, ESI MS, and chemical methods. Its structure was highly homologous to those from the two major members of the same Proteeae tribe, Proteus mirabilis and Providencia alcalifaciens, and analysis of the M. morganii genome disclosed that the loci for its outer core, lipid A and Ara4N moieties are similarly conserved.

Figure optionsDownload as PowerPoint slide