Total synthesis of the bacillosamine containing α-l-serine linked trisaccharide of Neisseria meningitidis

• Total syntheses of the l-serine linked bacillosamine containing trisaccharide, present on the pili of N. meningitidis.
• α-Stereoselective coupling of l-serine with bacillosamine.
• Installation of two consecutive α-glycosyl linkages.

Total synthesis of the bacillosamine containing l-serine linked O-trisaccharide of Neisseria meningitidis is described. The synthesis entails installation of two consecutive α-linkages including the coupling of bacillosamine with l-serine derivative.

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