Synthesis of a protected trihydroxyindolizidine 3-carboxylate via a hetero-Diels–Alder addition of ethyl 2-nitrosoacrylate to a d-ribose-derived exo-glycal

A protected trihydroxyindolizidine 3-carboxylate was prepared by a 6-endo epoxide cleavage, which in turn was intermediately formed from the hetero-Diels–Alder adduct of ethyl 2-nitrosoacrylate to a d-ribose-derived exo-glycal.

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