کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1388072 | 1500885 | 2013 | 8 صفحه PDF | دانلود رایگان |
The octahydropyrano[3,2-b]pyrrole derivatives are synthesized by a double reductive amination from pyranose derivatives of nono-2,5-diuloses and octos-4-uloses and various amines. The cyclization proceeded smoothly in the presence of sodium triacetoxyborohydride to produce a series of novel fused N-heterobicyclic compounds with high stereoselectivity.
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► We have disclosed a mild, convenient and efficient method for the stereoselective synthesis of a series of octahydropyrano[3,2-b]pyrrole derivatives by using glycosyl-1,4-dicarbonyl compounds.
► A new approach to the octahydropyrano[3,2-b]pyrrole derivatives, which has undergone the double reductive amination in the presence of sodium triacetoxy-borohydride in dichloromethane at room temperature, was first reported.
Journal: Carbohydrate Research - Volume 366, 25 January 2013, Pages 55–62