The synthesis of 2-deoxy-α-d-glycosides from d-glycals catalyzed by TMSI and PPh3

2-Deoxyglycosides were synthesized in high α-selectivity by the direct addition of alcohols to d-glucal and d-galactal catalyzed by TMSI and PPh3. The acid labile isopropylidene group is tolerated under this condition.

Figure optionsDownload as PowerPoint slide