Convenient synthesis of d- and l-xylo-1,2,3,4-alkane tetrols from a d-gluco-configured common building block

d-gluco-Configured building block derived from d-(+)-gluconolactone has served as a common chiral template for the synthesis of enantiopure d- and l-xylo-configured 1,2,3,4-alkane tetrols. This has enabled synthesis of medicinally important guggultetrols and their enantiomers from a common starting point. Wittig and Grignard reactions are the key steps used for the incorporation of lipophilic chain.

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► Valuable d-gluco-configured common building block from d-(+)-Gluconolactone.
► d-gluco-configured building block for the synthesis of Guggultetrols and their enantiomers.
► Synthesis of other alkane-1,2,3,4-tetrols with d- or l-xylo-configuration.