کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1388487 | 1500850 | 2015 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Chemoenzymatic synthesis of lacto-N-tetrasaccharide and sialyl lacto-N-tetrasaccharides
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
• Highly efficient one-pot two-enzyme large-scale synthesis of lacto-N-biose (LNB).
• Convergent chemical synthesis of LNT using enzymatic generated LNB disaccharide building block.
• Enzymatically synthesized building blocks for chemical synthesis with additional enzymatic modifications.
A concise and practical chemoenzymatic synthesis of lacto-N-tetraose, a major component and one of the most common core structures of human milk oligosaccharides (HMOs) was reported. This convergent synthesis relies on the glycosylation of a readily available lactoside acceptor with a lacto-N-biose donor generated from a highly efficient one-pot two-enzyme synthesis.
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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Carbohydrate Research - Volume 401, 12 January 2015, Pages 5–10
Journal: Carbohydrate Research - Volume 401, 12 January 2015, Pages 5–10
نویسندگان
Wenlong Yao, Jun Yan, Xi Chen, Fengshan Wang, Hongzhi Cao,