کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1388557 1500904 2008 13 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
C-5 Modifications in N-acetyl-neuraminic acid: scope and limitations
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
C-5 Modifications in N-acetyl-neuraminic acid: scope and limitations
چکیده انگلیسی

Glycoconjugates containing sialic acid are involved in a large variety of biological phenomena, including cell–cell adhesion, recognition by viruses and bacteria, and oncogenesis. Therefore, they are important synthetic targets for the design of drugs and vaccines. In the last decades, different methodologies that improve yield and stereoselectivity in sialylation reactions have been investigated. This review summarizes the latest developments in the synthesis of C-5 modified sialic acid glycosyl donors and glycosyl acceptors and their application in the synthesis of α-sialosides.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Carbohydrate Research - Volume 343, Issues 10–11, 21 July 2008, Pages 1540–1552
نویسندگان
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