کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1388560 1500904 2008 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Sialylation reactions with 5-N,7-O-carbonyl-protected sialyl donors: unusual stereoselectivity with nitrile solvent assistance
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Sialylation reactions with 5-N,7-O-carbonyl-protected sialyl donors: unusual stereoselectivity with nitrile solvent assistance
چکیده انگلیسی

A 5-N,7-O-carbonyl-protected sialyl donor was synthesized, and, unexpectedly, this donor showed β-selectivity (α/β = 1/2.4–1/20) on coupling with sugar acceptors in acetonitrile upon treatment with various promoter systems. For the coupling reaction in dichloromethane, a modified Ellervik’s method (IBr and AgClO4·H2O) was highly effective in activating the 5-N,7-O-carbonyl donor, providing moderate α-selectivity (α/β = ∼1.8/1).

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Carbohydrate Research - Volume 343, Issues 10–11, 21 July 2008, Pages 1585–1593
نویسندگان
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