کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1388785 | 982818 | 2009 | 5 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Modulating glycosidase degradation and lectin recognition of gold glyconanoparticles Modulating glycosidase degradation and lectin recognition of gold glyconanoparticles](/preview/png/1388785.png)
Glyconanoparticles (GNPs) are water-soluble carbohydrate-functionalized gold nanoclusters with a promising potential to serve as versatile tools in studies ranging from basic chemical glycobiology to clinical applications. In this paper we evaluate the influence of ligand density and presentation on the recognition by protein receptors by examining the interaction of lactose-functionalized GNPs with two different galactose-specific carbohydrate-binding proteins: an enzyme, Escherichia coli β-galactosidase, and a lectin, Viscum album agglutinin. The results suggest that the proper selection of ligand densities and spacers in GNP functionalization is an important requisite to match the topological requirements of the target receptor while escaping glycosidase degradation.
Stable to enzyme degradation and selective to target lectins, glyconanoparticles represent new tools for intervening in carbohydrate-mediated processes in vivo.Figure optionsDownload as PowerPoint slide
Journal: Carbohydrate Research - Volume 344, Issue 12, 17 August 2009, Pages 1474–1478