کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1389058 982839 2011 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A new approach for the N- and S-galactosylation of 5-arylidene-2-thioxo-4-thiazolidinones
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
A new approach for the N- and S-galactosylation of 5-arylidene-2-thioxo-4-thiazolidinones
چکیده انگلیسی

N- and S-galactosylation was carried out via the reaction of 5-((Z)-arylidene)-2-thioxo-4-thiazolidinones with 2,3,4,6-tetra-O-acetyl-α-d-galactopyranosyl bromide under alkaline conditions or under silylation conditions. Deacetylation of the N-galactosylation products was performed with concentrated hydrochloric acid in methanol (3.5%) or sodium methoxide in methanol without cleavage of the 2-thioxo-4-thaizolidinone ring by means of acid hydrolysis. The anomers were separated by flash column chromatography, and their configurations were assigned by NMR spectroscopy. The deprotected nucleosides were screened against leukemia L-1210 and were found inactive.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Carbohydrate Research - Volume 346, Issue 18, 27 December 2011, Pages 2831–2837
نویسندگان
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