کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1389425 | 982879 | 2009 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
A novel multicomponent synthesis of polyfunctionalized bicyclic tetrahydropyrimidinone derivatives via mercaptoacetylative ring transformations
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: A novel multicomponent synthesis of polyfunctionalized bicyclic tetrahydropyrimidinone derivatives via mercaptoacetylative ring transformations A novel multicomponent synthesis of polyfunctionalized bicyclic tetrahydropyrimidinone derivatives via mercaptoacetylative ring transformations](/preview/png/1389425.png)
چکیده انگلیسی
A novel K-10 clay (nanoclay)-catalyzed expeditious synthesis of polyfunctionalized bicyclic pyrimidines using unprotected aldoses, 2-methyl-2-phenyl-1,3-oxathiolan-5-one and amidines/guanidine is reported. These polyfunctionalized bicyclic pyrimidines were obtained in excellent yields (72-93%) with high cis diastereoselectivity (>94%) at the ring junction via tandem condensation, mercaptoacetylative ring transformation and cyclization reactions. The process presents an excellent illustration of use of carbohydrates as renewable resources for the formation of pharmaceutically relevant fine chemicals employing solvent-free microwave irradiation conditions in a one-pot procedure.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Carbohydrate Research - Volume 344, Issue 17, 23 November 2009, Pages 2329-2335
Journal: Carbohydrate Research - Volume 344, Issue 17, 23 November 2009, Pages 2329-2335
نویسندگان
Lal Dhar S. Yadav, Ankita Rai,