کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1389615 | 982904 | 2008 | 6 صفحه PDF | دانلود رایگان |

6-Oligo(lactic acid)cyclomaltoheptaose (6-OLA-βCD) with an average substitution of about 7.0 lactic acid units was prepared as a new water-soluble cyclomaltoheptaose (βCD) derivative (solubility of about 70.7-fold that of βCD), based on the ring-opening polymerization of 3,6-dimethyl-1,4-dioxane-2,5-dione (lactide). The product was characterized by 1H NMR, 13C NMR, IR, and MS spectroscopy. The complexation of amoxicillin with 6-OLA-βCD was found to be much stronger than that with βCD at first, and then 6-OLA-βCD was shown to decompose moderately into βCD and lactic acid. 6-OLA-βCD might be greatly valuable in a controlled release system for Amoxicillin (AMX).
A new water-soluble cyclomaltoheptaose derivative, 6-oligo(lactic acid)cyclomaltoheptaose (6-oligo(lactic acid)-βCD) for the controlled release of the common drug Amoxicillin (AMX).Figure optionsDownload as PowerPoint slide
Journal: Carbohydrate Research - Volume 343, Issue 15, 13 October 2008, Pages 2517–2522