Synthesis of 6-phosphofructose aspartic acid and some related Amadori compounds

• A critical solubility problem was overcome to enable the synthesis of 6-phosphofructose-aspartic acid.
• A detailed nmr analysis (proton, carbon, and phosphorus) is given.
• We also report improved syntheses of fructose-asparagine and of fructose-aspartic acid.

We describe the synthesis and characterization of 6-phosphofructose-aspartic acid, an intermediate in the metabolism of fructose-asparagine by Salmonella. We also report improved syntheses of fructose-asparagine itself and of fructose-aspartic acid.

Figure optionsDownload as PowerPoint slide