کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1390076 1500825 2016 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synthesis of a hybrid type N-glycan heptasaccharide oxazoline for Endo M catalysed glycosylation
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Synthesis of a hybrid type N-glycan heptasaccharide oxazoline for Endo M catalysed glycosylation
چکیده انگلیسی


• Convergent synthesis of a hybrid type N-glycan heptasaccharide.
• Global de-protection by Birch reduction.
• Oxazoline formation in water.
• Endo M catalysed glycosylation of a GlcNAc-Asn glycosyl amino acid.

Endo-β-N-acetylglucosaminidases (ENGases) are versatile biocatalysts that allow access to a wide variety of defined homogenous N-linked glycoconjugates in a convergent manner. A hybrid-type N-glycan was accessed by total synthesis, converted to an oxazoline, and used as a donor substrate with both wild type Endo M and an N175Q glycosynthase Endo M mutant allowing the convergent synthesis of a glycosylated amino acid bearing a hybrid N-glycan structure.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Carbohydrate Research - Volume 426, 13 May 2016, Pages 40–45
نویسندگان
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