An efficient synthesis of novel bis-triazole glycoconjugates via a three-component condensation as a key reaction

• Novel bis-triazole linked glycoconjugates were designed and synthesized.
• Utilizing a three-component condensation as a key step to reduce reaction steps.
• Structure/reactivity study of intermediate N2-hydroxymethyl triazole was emphasized.
• The novel glycoconjugates would be provided with potential antivirus activity.

Novel bis-triazole glycoconjugates were designed and prepared successfully via 5 steps from propargyl per-O-acetyl-β-d-glucoside or xyloside (total yield of 48–53%), after utilizing a three-component condensation of propargyl per-O-acetyl-β-d-glycoside, formaldehyde, and sodium azide as a key step to synthesize 2-hydroxymethyl-2H-1,2,3-triazole glycoconjugates. The developed bis-triazole glycoconjugates would be crucial in antivirus pharmacology and chemical biology.

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