Synthesis and antimicrobial activity of 6-triazolo-6-deoxy eugenol glucosides

• First time synthesis of eugenol glucosides with different triazole moieties.
• Impressive antimicrobial activities against Salmonella typhimurium and Micrococcus luteus.
• Low cytotoxicity on normal host cells.

A new series of 1,2,3-triazole eugenol glucosides were synthesized. The new compound structures were confirmed by MS, 1H NMR and 13C NMR. All of the synthesized compounds were screened for antimicrobial and cytotoxic activity. Five compounds exerted significant activity against the Gram-negative bacteria Salmonella typhimurium with low IC50 values (49.73–68.53 μΜ), and seven compounds were active against the Gram-positive bacteria Micrococcus luteus (42.89–210.94 μM). In vitro cytotoxicity on mouse spleen cells was also evaluated. One compound bearing a phenyl substituent at the triazole ring showed good activity against Salmonella typhimurium (49.73 μM) and low toxicity to normal cells (CC50=157.83 μM). Thus, the compounds herein can be considered for further modification for improving their antibacterial activity or obtaining novel antibacterial drug candidates.

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