کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1390288 1500877 2013 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Stereoselective synthesis of (2S,3S,4R,5S)-3,4-dihydroxy-2,5-dihydroxymethyl pyrrolidine from l-sorbose
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Stereoselective synthesis of (2S,3S,4R,5S)-3,4-dihydroxy-2,5-dihydroxymethyl pyrrolidine from l-sorbose
چکیده انگلیسی


• We have developed a new method to produce DMDP.
• This method can give access to several analogues for structures/activities relationships.
• A stereoselective reduction has been observed and rationalised.

One of the most frequently synthesized iminosugar derivatives is DMDP. Starting from l-sorbose, a practical method for the synthesis of derivatives of this five-membered iminocyclitol has been developed, involving straightforward steps and a convenient selective reduction of a ketoxime intermediate.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Carbohydrate Research - Volume 374, 7 June 2013, Pages 14–22
نویسندگان
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