Synthesis of branched arabinofuranose pentasaccharide fragment of mycobacterial arabinans as 2-azidoethyl glycoside

Branched arabinofuranose pentasaccharide with 2-azidoethyl aglycon was prepared for the first time by [3+1+1] bis-(1,2-cis)-glycosylation of trisaccharide diol with silyl-protected thioglycoside glycosyl donor. The presence of 2-azidoethyl aglycon would enable the preparation of neoglycoconjugates using the click chemistry approaches.

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► Branched arabinofuranose pentasaccharide with 2-azidoethyl aglycon was prepared.
► O-Benzyl groups were not required for synthesis of the title oligosaccharide.
► 2-Azidoethyl aglycon would enable the preparation of neoglycoconjugates.