A facile one-pot synthesis of biphenyl methyl-C-β-d-glycosides

Facile one-pot synthesis of biphenyl methyl-C-β-d-glycosides was carried out using 4,6-O-protected-C-glycoside, aromatic aldehydes and malononitrile in pyrrolidine as an organocatalyst. Studies reveal that the use of pyrrolidine resulted in a better yield.

Facile one-pot synthesis of biphenyl methyl-C-β-d-glycosides was carried out using 4,6-O-protected-C-glycoside, aromatic aldehydes and malononitrile in pyrrolidine as an organocatalyst. Studies reveal that the use of pyrrolidine resulted in better yield.Figure optionsDownload as PowerPoint slideHighlights
► Synthesis of glycosidic ketones.
► Multi-functional biphenyl methyl-C-β-d-glycosides by one pot reactions.
► Optimization of experimental conditions.