کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1390381 1500897 2012 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Efficient activation of thioglycosides with N-(p-methylphenylthio)-ε-caprolactam-TMSOTf
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Efficient activation of thioglycosides with N-(p-methylphenylthio)-ε-caprolactam-TMSOTf
چکیده انگلیسی

Figure optionsDownload as PowerPoint slideN-(p-Methylphenylthio)-ε-caprolactam (1) in combination with trimethylsilyl trifluoromethanesulfonate (TMSOTf) provides an efficient thiophilic promoter system, capable of activating different thioglycosides. Both ‘armed’ and ‘disarmed’ thioglycosyl donors were activated for glycosidic bond formation. Notably, this reagent combination works well in reactivity-based one-pot oligosaccharide assembly strategy.

Figure optionsDownload as PowerPoint slideHighlights
► N-(p-Methylphenylthio)-ε-caprolactam-TMSOTf acts as efficient activator for glycosylation reaction based on thioglycosides.
► Both armed and disarmed thioglycosyl donors are activated.
► The reagent system works well in reactivity based one-pot oligosaccharide assembly.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Carbohydrate Research - Volume 354, 1 June 2012, Pages 40–48
نویسندگان
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