کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1390411 | 1500901 | 2012 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Synthesis of a sulfonic acid mimetic of the sulfated Lewis A pentasaccharide
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Synthesis of a sulfonic acid mimetic of the sulfated Lewis A pentasaccharide Synthesis of a sulfonic acid mimetic of the sulfated Lewis A pentasaccharide](/preview/png/1390411.png)
چکیده انگلیسی
The first sulfonic acid mimetic of the sulfated Lewis A pentasaccharide in which the natural l-fucose unit is replaced by a d-arabinose ring was synthesized. Formation of the sulfonic acid moiety at a pentasaccharide level could be successfully achieved by means of introduction of an acetylthio moiety into the terminal d-galactose residue and subsequent oxidation. The equatorial arrangement of the acetylthio group linked to C-3 of the galactose ring could be obtained by double nucleophilic substitutions; efficient formation of the gulo-triflate derivatives required low-power microwave (MW) activation. Oxidation of the acetylthio group was carried out using Oxone in the presence of acetic acid.
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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Carbohydrate Research - Volume 350, 1 March 2012, Pages 90–93
Journal: Carbohydrate Research - Volume 350, 1 March 2012, Pages 90–93
نویسندگان
Zsolt Jakab, Anikó Fekete, Magdolna Csávás, Anikó Borbás, András Lipták, Sándor Antus,