کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1390458 | 983078 | 2011 | 10 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Synthesis and antibacterial evaluation of a series of oligorhamnoside derivatives Synthesis and antibacterial evaluation of a series of oligorhamnoside derivatives](/preview/png/1390458.png)
A series of novel oligorhamnoside derivatives (1–10) and naturally occurring cleistrioside-5 were synthesized and evaluated for their in vitro antibacterial activities. Among them, dirhamnoside derivative 7 and cleistrioside-5 displayed similar antibacterial profiles and exhibited moderate to good inhibitory activities on bacterial growth against a panel of Gram-positive bacteria (MICs ⩽ 4–32 μg/mL). The results revealed that these two compounds showed selectivity towards bacterial species strictly, without being affected by the antibiotic-resistant/susceptible properties of one species, which suggested that they might have the potential to avoid antibiotic cross-resistance. In addition, the preliminary SARs of this type of oligorhamnoside derivatives on the antibacterial activities were determined.
Partially acetylated oligorhamnoside derivatives as antibacterial agents (MICs ⩽ 4–32 μg/mL).Figure optionsDownload as PowerPoint slide
Journal: Carbohydrate Research - Volume 346, Issue 14, 18 October 2011, Pages 2126–2135