کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1390493 | 983088 | 2011 | 7 صفحه PDF | دانلود رایگان |

Two water-soluble chitosan (WSC) derivatives of N-succinyl-chitosan (NSCS) and N,O-succinyl-chitosan (NOSCS) with a degree of substitution (DS) that ranged form 0.28 to 0.61 were selectively synthesized by varying the molar ration of succinic anhydride and chitosan. The chemical structure and physical properties of the chitosan derivatives were characterized by FT-IR, 1H NMR, and XRD. XRD analysis showed that the derivatives were amorphous. The lysozyme enzymatic degradation results revealed that the NSCS was of higher susceptibility to lysozyme. The degradation rate and the solubility of the chitosan derivatives were strongly determined by the degree of substitution and the position of the substitution. The results of antithrombotic properties, hemolytic properties and anticoagulant properties of WSCs indicated that the blood compatibility was dramatically improved, and the carboxyl group introduced on the C-6 or C-2 hydroxyl group appeared to impact anticoagulant activity in different ways.
Both N,O-succinyl-chitosan (NOSCS) and N-succinyl-chitosan (NSCS) showed magnificent blood compatibility, while the anticoagulant property indicated that NSCS was better. Enzymatic degradation assay demonstrated that the NSCS was more susceptible to lysozyme than NOSCS with similar degree of substitution.Figure optionsDownload as PowerPoint slide
Journal: Carbohydrate Research - Volume 346, Issue 10, 15 July 2011, Pages 1217–1223