کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1390724 983132 2008 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Depiction of the forces participating in the 2-O-sulfo-α-l-iduronic acid conformational preference in heparin sequences in aqueous solutions
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Depiction of the forces participating in the 2-O-sulfo-α-l-iduronic acid conformational preference in heparin sequences in aqueous solutions
چکیده انگلیسی

2-O-Sulfo-α-l-iduronic acid (IdoA2S) is one of the main components of heparin, an anticoagulant and antithrombotic polysaccharide able to potentiate the inhibitory effect of antithrombin over plasma serine proteases. This monosaccharide unit adopts an equilibrium between chair (1C4) and skew-boat (2SO) forms as a function of heparin sequence size and composition. Although the prevalence of the 1C4 chair conformation in monosaccharides is understood, the reasons for the increase in 2SO contribution in the whole polysaccharide chain are still uncertain. In this context, 0.2 μs molecular dynamics simulations of IdoA2S-containing oligosaccharides indicated that stabilization due to intramolecular hydrogen bonds around IdoA2S is highly correlated (p ⩽ 0.001) with the expected conformational equilibrium for this residue in solution. This behavior explains the known effect of different heparin compositions, at the monosaccharide level, on IdoA2S conformation in biological solutions.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Carbohydrate Research - Volume 343, Issue 9, 7 July 2008, Pages 1435–1445
نویسندگان
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