کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1390815 1500905 2007 18 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Recent advances in the glycosylation of sphingosines and ceramides
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Recent advances in the glycosylation of sphingosines and ceramides
چکیده انگلیسی

Glycosphingolipids (GSLs) are ubiquitous components of eukaryotic cell membranes. They are highly bioactive and are involved in many aspects of cell signalling like cell–cell interaction, cell–substratum interaction and cell–pathogen interaction. GSLs also are involved in the modulation of signal transduction, resulting in regulation of cell proliferation and differentiation. The biological importance and complexity of these compounds afford many opportunities to prepare synthetic analogues for studies of their metabolism in intra- and intercellular processes. This review focuses on recent contributions in the synthesis of GSLs, highlighting improvements in glycosylation reactions leading to α and β glycosyl sphingosines and ceramides and related compounds. Literature from 2000 to the present is covered. The glycosylation reactions leading to the synthesis of GSLs are classified in function of the configuration of the created glycosidic bond (α or β) and of the acceptor used, either azido-sphingosine or ceramide.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Carbohydrate Research - Volume 342, Issues 12–13, 3 September 2007, Pages 1595–1612
نویسندگان
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