کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1390818 1500905 2007 15 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synthesis of C-4 and C-7 triazole analogs of zanamivir as multivalent sialic acid containing scaffolds
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Synthesis of C-4 and C-7 triazole analogs of zanamivir as multivalent sialic acid containing scaffolds
چکیده انگلیسی

The relative reactivities of C-4 and C-7 azides derived from zanamivir were compared in cycloaddition reactions with a panel of alkynes. All of the reactions proceeded efficiently with no observable differences between primary and secondary azides. Significant rate differences were observed between several members of the alkyne panel. Most notably, a trialkyne derived from a 1,3,5-triazine core underwent complete reaction within 4 h, whereas an analogous trialkyne with an all carbon aromatic core required 18 h. These results suggest that the triazine core serves as an internal catalyst.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Carbohydrate Research - Volume 342, Issues 12–13, 3 September 2007, Pages 1636–1650
نویسندگان
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