کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1390976 983172 2006 23 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synthesis of N-glycan oxazolines: donors for endohexosaminidase catalysed glycosylation
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Synthesis of N-glycan oxazolines: donors for endohexosaminidase catalysed glycosylation
چکیده انگلیسی

Oxazoline mono-, di-, tri- and hexasaccharides, corresponding to the core components of N-linked glycoprotein high mannose glycans, are synthesised as potential glycosyl donors for endohexosaminidase catalysed glycosylation of glycopeptides and glycoprotein remodelling. The crucial β-d-Manp-(1→4)-d-GlcpNAc linkage is synthesised via epimerisation of gluco disaccharide substrates by sequential triflation and nucleophilic substitution. Oxazolines are formed directly from the anomeric OPMP protected N-acetyl glucosamine derivatives. Efficient endohexosaminidase catalysed glycosylation of a synthetic β-d-GlcpNAcAsn glycosyl amino acid is demonstrated with the trisaccharide oxazoline donor.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Carbohydrate Research - Volume 341, Issue 10, 24 July 2006, Pages 1574–1596
نویسندگان
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