کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1390990 | 983172 | 2006 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Fine tuning of β-glucosidase inhibitory activity in the 2,5-dideoxy-2,5-imino-d-mannitol (DMDP) system
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Based on our extensive studies of d-glucosidase inhibiting 2,5-dideoxy-2,5-imino-d-mannitol derivatives, we have been trying to create a series of fluorescent derivatives with a view to an ‘inhibitory activity ruler’ based on competitive displacement reactions of non-fluorescent inhibitors by fluorescent ones and vice versa, which can be performed and followed in microtiter plates or on-chips. Thus, a set of compounds was assembled with Ki values between 2 nM and 1 μM against Agrobacterium sp. β-glucosidase.
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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Carbohydrate Research - Volume 341, Issue 10, 24 July 2006, Pages 1717–1722
Journal: Carbohydrate Research - Volume 341, Issue 10, 24 July 2006, Pages 1717–1722
نویسندگان
Tanja M. Wrodnigg, Arnold E. Stütz, Chris A. Tarling, Stephen G. Withers,