کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1391779 983641 2006 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Small-Molecule Compounds that Modulate Lipolysis in Adipose Tissue: Targeting Strategies and Molecular Classes
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Small-Molecule Compounds that Modulate Lipolysis in Adipose Tissue: Targeting Strategies and Molecular Classes
چکیده انگلیسی

Lipolysis is an important pathway in maintaining energy homeostasis through the degradation of triglycerides in adipose tissue and the release of fatty acids into the circulation as an energy source. However, an elevated level of circulating fatty acids leads to unfavorable metabolic effects such as insulin resistance and dyslipidemia. Cell surface receptors and intracellular components of the lipolytic pathway have been targeted to develop antilipolytic agents, among which are G-protein-coupled receptor agonists and lipase inhibitors. In addition, molecules that stimulate lipolysis have been tested in clinical trials as a treatment for obesity. Together, these molecules represent a diverse group of regulators for this pathway. This review will discuss strategies to target lipolysis and the major issues with representative small-molecule modulators of this pathway.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 13, Issue 10, October 2006, Pages 1019–1027
نویسندگان
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