کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1391895 983662 2006 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The Acylation State of Mycobacterial Lipomannans Modulates Innate Immunity Response through Toll-like Receptor 2
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
The Acylation State of Mycobacterial Lipomannans Modulates Innate Immunity Response through Toll-like Receptor 2
چکیده انگلیسی

SummaryDetection of Mycobacterium tuberculosis antigens by professional phagocytes via toll-like receptors (TLR) contributes to controlling chronic M. tuberculosis infection. Lipomannans (LM), which are major lipoglycans of the mycobacterial envelope, were recently described as agonists of TLR2 with potent activity on proinflammatory cytokine regulation. LM correspond to a heterogeneous population of acyl- and glyco-forms. We report here the purification and the complete structural characterization of four LM acyl-forms from Mycobacterium bovis BCG using MALDI MS and 2D 1H-31P NMR analyses. All this biochemical work provided the tools to investigate the implication of LM acylation degree on its proinflammatory activity. The latter was ascribed to the triacylated LM form, essentially an agonist of TLR2, using TLR2/TLR1 heterodimers for signaling. Altogether, these findings shed more light on the molecular basis of LM recognition by TLR.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 13, Issue 1, January 2006, Pages 39–47
نویسندگان
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