کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1392 | 83 | 2010 | 8 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Design and evaluation of novel polyanhydride blends as nerve guidance conduits Design and evaluation of novel polyanhydride blends as nerve guidance conduits](/preview/png/1392.png)
Implantable biodegradable nerve guidance conduits (NGCs) have the potential to align and support regenerating cells, as well as prevent scar formation. In this study in vitro bioassays and in vivo material evaluations were performed using a nerve guidance conduit material made from a novel polyanhydride blend. In vitro cytotoxicity studies with both fibroblasts and primary chick neurons demonstrated that the proposed polyanhydride blend was non-cytotoxic. Subcutaneous implantation for 7 days in rats resulted in an initial fibrin matrix, minimal macrophage presence and angiogenesis in the surrounding tissues. Nerve guidance conduits fabricated from the proposed polyanhydride blend material may serve as favorable biocompatible tissue engineering devices.
Journal: Acta Biomaterialia - Volume 6, Issue 6, June 2010, Pages 1917–1924