کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1392841 | 983780 | 2007 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Synthesis of Polyester by Means of Genetic Code Reprogramming
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Synthesis of Polyester by Means of Genetic Code Reprogramming Synthesis of Polyester by Means of Genetic Code Reprogramming](/preview/png/1392841.png)
چکیده انگلیسی
SummaryHere we report the ribosomal polymerization of α-hydroxy acids by means of genetic code reprogramming. The flexizyme system, a ribozyme-based tRNA acylation tool, was used to reassign individual codons to seven types of α-hydroxy acids, and then polyesters were synthesized under controls of the reprogrammed genetic code using a reconstituted cell-free translation system. The sequence and length of the polyester segments were specified by the mRNA template, indicating that high-fidelity ribosome expression of polyesters was possible. This work opens a door for the mRNA-directed synthesis of backbone-altered biopolymers.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 14, Issue 12, 26 December 2007, Pages 1315–1322
Journal: - Volume 14, Issue 12, 26 December 2007, Pages 1315–1322
نویسندگان
Atsushi Ohta, Hiroshi Murakami, Eri Higashimura, Hiroaki Suga,